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Unraveling the molecular mechanisms underlying TDP-43 proteinopathies.

In our lab, we study the molecular mechanisms underlying TDP-43 proteinopathies, which include frontotemporal degeneration (FTD-TDP), amyotrophic lateral sclerosis (ALS), and Alzheimer's disease (AD), among others. We employ both in vitro and in vivo models to replicate neuropathological features, aiming to elucidate the mechanisms of neurodegeneration.