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Mentor Areas

The Greenberg laboratory is interested in identifying basic mechanisms involved in maintaining genome integrity and understanding their relationship to human malignancy. In particular, we are devoted to the elucidation of BRCA1-dependent signaling pathways necessary for appropriate repair of DNA double strand breaks and suppression of breast and ovarian cancer.

Description:

Dr. Greenberg's laboratory is devoted to understanding how basic mechanisms of DNA repair impact cancer etiology and response to targeted therapies. As a focal point to interrogate these interrelationships, we are devoted to the elucidation of BRCA1- and BRCA2- dependent homologous recombination DNA repair mechanisms and their roles in breast and ovarian cancer susceptibility. We have more recently developed an additional focus on cancer associated telomere length maintenance mechanisms that rely on a specialized form of homologous recombination. Additionally, we have developed new insights into how DNA damage responses activate inflammatory cytokine signaling networks that influence immune responses to cancer. We utilize a myriad of approaches to investigate these areas, which include biochemistry, structural biology, cell biology, and genetically engineered mouse models.

Projects are determined after discussion with the student.

Preferred Qualifications

No specific qualifications.

Project Website

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Research Description

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Preferred Student Year

First-year, Second-Year, Junior, Senior

Academic Term

Fall, Spring, Summer

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Volunteer

Yes

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Paid

Yes

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Work Study

Yes

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