Mentor Areas
The cells of different tissues have the same genome but are phenotypically distinct. Cell identity programs are thus epigenetic in nature, as they are not driven by changes in the DNA sequence. How do these epigenetic processes work, and why are we so interested in and fascinated by them? We study the contribution of chromatin states to epigenetic programs. Covalent modifications of histones and DNA offer a powerful mode for encoding and propagating epigenetic information. Long-standing models of lineage specification propose that epigenetic processes help enforce cell fate decisions and maintain differentiated cellular identities. However, the mechanisms by which transient stimuli are converted into stable cell fate outputs are poorly understood, and misregulation of this process can lead to cellular disease states such as cancer. By using a combination of high-throughput genetic screening, epigenomic profiling, and chromatin-focused biochemistry, we aim to address these and related questions.
Description:
Projects will vary. Interested students should contact us to discuss possibilities.
Preferred Qualifications
Prior research experience (outside of classwork) in molecular/cellular biology required.
Details:
Preferred Student Year
First-year, Second-Year, Junior, Senior
Academic Term
Fall, Spring, Summer
I prefer to have students start during the above term(s).Volunteer
No
Yes indicates that faculty are open to volunteers.Paid
No
Yes indicates that faculty are open to paying students they engage in their research, regardless of their work-study eligibility.Work Study
Yes
Yes indicates that faculty are open to hiring work-study-eligible students.