Pediatric Gastrointestinal (GI) Motility Disorders

Mentor Areas

approved training program in pediatric motility disorders for 10 years.

My key interests include gastroparesis, gastric electric stimulation, Intestinal pseudoobstruction, swallowing disorders, constipation, cecostomy, sacral nerve stimulation, rumination, gastroesophageal reflux, Hirschsprung's disease, gastrointestinal motility diseases, rumination, and other functional disorders. I have special clinical expertise in managing patients in multidisciplinary settings and had an active role in developing both aerodigestive and colorectal multidisciplinary teams.

1. Innovation in high resolution electrogastrography: In collaboration with biomedical engineering, validated the non-invasive high resolution electrogastrography (EGG) by simultaneously performing antroduodenal manometry studies and HR-EGG using a wearable multi-channel system and artifact removal signal processing methods. Our approach yielded an increase of 0.56 in the mean correlation coefficient between EGG and the clinical gold standard antroduodenal manometry, across all subjects (p<0.001). Then, we evaluated the benefits of using cutaneous high-resolution electrogastrography (HR-EGG) in subjects with active foregut symptoms and found that abnormal spatial parameters, detected by cutaneous HR-EGG, correlated with severity of upper gastrointestinal symptoms, regardless of gastric emptying. This non-invasive diagnostic study has the potential of leading therapeutic intervention in patients with foregut functional symptoms. My goals are now to offer this technique to patients with functional GI disorders and implement interventions based on their personal gastric rhythm. 
2. Innovation in EndoFLIP technique: Understanding the pathophysiology of dysphagia and offering cure were the drive to master EndoFLIP technique in patients with dysphagia. I collaborated with biomedical engineering and created program for an automated analysis of the dynamic changes and dispensability findings. In this prospective study, we aimed to investigate whether esophageal compliance is a more sensitive measure than esophageal dispensability in detecting epithelial remodeling on regional and global esophageal levels in children with eosinophilic esophagitis (EoE) compared to controls.  We hypothesized that compliance is a stronger indicator of remodeling than distensibility. We standardized the protocol for the FLIP catheter position, and we collaborated with biomedical engineering to develop an automated analysis protocol.
3. Innovation in neuromodulation of the gastrointestinal tract: I have also examined gastric pacing in the management of patients with gastroparesis and evaluated the benefits of gastric electric stimulation on children with gastroparesis and functional dyspepsia. In addition, I evaluated the use of sacral nerve stimulation in patient with defecation disorders. I studied the value of colonic motility in predicting the outcome of cecostomy placement in patients with severe constipation. 
4. Innovation in a non-invasive assessments of gastrointestinal transit time.  I have also investigated the sensitivity and validity of the Wireless Motility Capsule Test in diagnostic capsule endoscopy in children. 

Description:

as mentioned above 

Preferred Qualifications

Interest in pediatric GI

Interest in biomedical 

Project Website

Learn more about the researcher and/or the project here.
https://www.research.chop.edu/people/hayat-mousa