Mentor Areas
We have pioneered the development of high-throughput, sequencing-based approaches to simultaneously study RNA secondary structure and RNA-protein interactions on a global scale. To do this, we have married classical nuclease-based structure mapping techniques with high-throughput sequencing technology to interrogate the protein binding profile and pairing status of all nucleotides in the RNA molecules of eukaryotic organisms. We believe that the findings from these approaches highlight the importance of RNA-protein interactions and RNA secondary structure in eukaryotes and present an approach that should be widely applicable for the analysis of these key features in any and all organisms.
We also make use of genomic, bioinformatic, and systems biology approaches with molecular genetic and biochemical techniques to identify and characterize the post-transcriptional regulatory effects of RNA covalent modifications in eukaryotic transcriptomes.
Description:
Projects will vary. Interested students should contact us to discuss possibilities.
Preferred Qualifications
No specific qualifications.
Details:
Preferred Student Year
First-year, Second-Year
Academic Term
Fall, Spring, Summer
I prefer to have students start during the above term(s).Volunteer
Yes
Yes indicates that faculty are open to volunteers.Paid
No
Yes indicates that faculty are open to paying students they engage in their research, regardless of their work-study eligibility.Work Study
Yes
Yes indicates that faculty are open to hiring work-study-eligible students.