Andrew Edmondson

Models of Genetic Neurodevelopmental Disorders

My lab studies rare genetic neurodevelopmental disorders that disrupt glycosylation (the enzyme-mediated process by which a carbohydrate, or “glycan”, is covalently attached to a target macromolecule) known as Congenital Disorders of Glycosylation, or CDG. In the nervous system, key proteins involved in neurotransmitter release, neuronal cell signaling, and cellular migration events are glycosylated, yet our understanding of the role of glycosylation in these processes is rudimentary. The scholar will use model systems (primary cells, iPSCs, mouse), a variety of molecular and cell biology techniques, and glycoproteomics to study glycosylation in the brain.