Mentor Areas
Protein biochemistry, cellular and molecular biology, immunofluorescence, transgenic mouse model, behavioral analysis.
Description:
While the etiology of FRDA is well understood, the disease's precise pathophysiology is less well defined, particularly with regard to the pathogenesis of cardiomyopathy, which results in the heart failure and mortality in FRDA patients. Treatment options are currently very limited for FRDA patients, with Omaveloxolone being the only drug approved at present for FRDA patients 16 years of age and older, necessitating development of further agents. The main objective of my research is to investigate the molecular basis underlying the pathogenesis of neurodegeneration and cardiomyopathy using cellular, molecular and proteomic approaches as well as transgenic mouse models in order to create therapeutic targets for FRDA.
Preferred Qualifications
I am open to to students with no experience, just a strong interest in biomedical research.
Project Website
Learn more about the researcher and/or the project here. https://www.med.upenn.edu/apps/faculty/index.php/g275/p18956
Details:
Preferred Student Year
Junior, Senior
Academic Term
Fall, Spring, Summer
I prefer to have students start during the above term(s).Volunteer
Yes
Yes indicates that faculty are open to volunteers.Paid
No
Yes indicates that faculty are open to paying students they engage in their research, regardless of their work-study eligibility.Work Study
Yes
Yes indicates that faculty are open to hiring work-study-eligible students.