Mentor Areas
- Molecular Biology
- Virology
- Cancer Biology
- Immunotherapy
- Nanotechnology
- Biochemistry
- Cell Biology
Description:
Dr. Jianxin You’s laboratory in the Department of Microbiology at the University of Pennsylvania Perelman School of Medicine investigates how oncogenic viruses interact with their host cells to drive cancer development (Cell 117:349–360; Cell Host Microbe 19:775–87). The lab also develops nanotechnology-based immunotherapies to stimulate antiviral and antitumor immune responses against virus-induced human cancers (Proc Natl Acad Sci U S A. 2020;117:13730–13739).
Our research takes a multidisciplinary approach, integrating biochemistry, molecular biology, virology, and cell biology, to uncover the molecular mechanisms of tumor virus infection and to design innovative therapeutic strategies that block viral oncogenesis. We also employ advanced AI tools, such as machine learning models and deep learning-based image analysis, to interpret complex datasets in cancer immunology research, accelerating discovery and therapeutic design.
Undergraduate researchers will gain hands-on experience with techniques such as molecular cloning, protein purification, cell culture, Western blotting, quantitative PCR, immunofluorescent staining, and fluorescence in situ hybridization, as well as participate in general lab maintenance and organization. Students will also learn how to design experiments, make intellectual contributions, and have opportunities to co-author publications.
Preferred Qualifications
- Strong Academic Performance: High GPA, particularly in relevant coursework like biology, chemistry, and other life sciences.
- Lab Experience: Previous experience in a research lab or coursework that includes lab components.
- Technical Skills: Familiarity with lab techniques such as PCR, microscopy, or data analysis software.
- Critical Thinking: Ability to analyze data, troubleshoot experiments, and think independently.
- Communication Skills: Strong written and verbal communication skills for writing reports and presenting findings.
- Attention to Detail: Precision in conducting experiments and recording results.
- Teamwork: Ability to work well in a collaborative environment.
- Passion for Research: Demonstrated interest in biomedical research through coursework, projects, or extracurricular activities.
- Time Management: Ability to manage time effectively, balancing lab work with academic responsibilities.
- Highly Motivated: Enthusiastic about learning and contributing to research.
- Responsible and Punctual: Reliable and consistent in attendance and meeting deadlines.
Project Website
Learn more about the researcher and/or the project here. Faculty Profile
Details:
Preferred Student Year
First-year, Second-Year, Junior, Senior
Academic Term
Fall, Spring, Summer
I prefer to have students start during the above term(s).Volunteer
Yes
Yes indicates that faculty are open to volunteers.Paid
Yes
Yes indicates that faculty are open to paying students they engage in their research, regardless of their work-study eligibility.Work Study
Yes
Yes indicates that faculty are open to hiring work-study-eligible students.