Mentor Areas
Our laboratory has two areas of interest – eicosanoid biology and molecular clocks.
In the case of eicosanoids, we are interested in the role they play in modulating the immune response in atherosclerosis and cancer, the promotion and restraint of cardiopulmonary fibrosis, in the response to viral infection and in stem cell biology. We are interested in the many factors that contribute to variability in the response to NSAIDs, including the microbiome, genomics, time of drug administration and metabolomics; the use of dynamic and network-based modelling to study drug response and the use of AI and machine learning approaches to develop paradigms predictive of efficacy and risk.
In the case of clocks, we are interested in how a decline in oscillatory function may contribute to age related phenotypes. We are integrating multiple remote sensing approaches with multi-omics analyses to characterize the human chronobiome and to identify time dependent networks that decline with age. Besides affording insight into the trajectory of aging this may afford the opportunity to obtain, in an unbiased fashion, mechanistic insights into time dependent disease phenotypes, such as non-dipping hypertension.
Description:
We are currently interested in bioactive lipids such as prostaglandins and in taking a systems approach to understanding variability in response to their inhibitors such as aspirin and other NSAIDs. We are also interested in elucidating the role of molecular clocks in cardiometabolism and aging. In both cases we apply sophisticated multi-omics and informatics approaches to studies in cells, model systems and humans.
Preferred Qualifications
Prior laboratory experience is desirable but being smart, enthusiastic, focused and willing to work hard is even more important.
Project Website
Learn more about the researcher and/or the project here. FitzGerald Lab
Details:
Preferred Student Year
Junior, Senior
Academic Term
Fall, Spring, Summer
I prefer to have students start during the above term(s).Volunteer
No
Yes indicates that faculty are open to volunteers.Paid
Yes
Yes indicates that faculty are open to paying students they engage in their research, regardless of their work-study eligibility.Work Study
Yes
Yes indicates that faculty are open to hiring work-study-eligible students.