Studying the dialogue between the microbiome and the immune system
Our lab studies the effect of the microbiome on the immune system in health, disease and therapy.
Research in Reproductive Immunology
We study how inflammation in the uterus helps the embryo to implant and develop its placenta.
Genome engineering of human induced pluripotent stem cells to study blood disorders
Human induced pluripotent stem cells (iPSCs) are somatic cells that have been reprogrammed to a pluripotent state that allows them to differentiate into any cell type. The ability to genetically engineer iPSCs is essential for generating tools to study human diseases and biological processes.
Models of Genetic Neurodevelopmental Disorders
My lab studies rare genetic neurodevelopmental disorders that disrupt glycosylation (the enzyme-mediated process by which a carbohydrate, or “glycan”, is covalently attached to a target macromolecule) known as Congenital Disorders of Glycosylation, or CDG. In the nervous system, key proteins involved in neurotransmitter release, neuronal cell signaling, and cellular migration events are glycosylated, yet our understanding of the role of glycosylation in these processes is rudimentary. The scholar will use model systems (primary cells, iPSCs, mouse), a variety of molecular and cell biology techniques, and glycoproteomics to study glycosylation in the brain.
Intersectional Health Promotion and Prevention of Sexual and Gender Diverse Youth
Dr. Sanders work focuses on building intersectional health promotion and prevention interventions for sexual and gender diverse youth, with a particular focus on expanding access to gender affirming care and optimizing adolescent and young adult sexual health, HIV/AIDS, and substance treatment and prevention interventions.
Psychosocial Functioning in Children with Inflammatory Bowel Disease
My research focuses on the psychosocial functioning of children and teens with inflammatory bowel disease (IBD). I am particularly interested in parental stress, treatment adherence, and child psychosocial outcomes for children with very early-onset IBD. I am also actively involved in depression and anxiety screening integrated within standard GI clinical care.
Studying cell migration in confined microenvironments
When cells grow or move within dense microenvironments their nuclei are subjected to different degrees of deformation. We investigate the mechanisms underlying migratory strategies, cell function and cell fate in scenarios where cells experience mechanical stress.
Advanced Imaging in Pediatric Brain Tumors
Imaging of pediatric brain tumors with advanced MRI techniques.
Behavioral Economics and Rehabilitation
I study how to use insights from behavioral economics to improve physical activity for adults after a stroke or with Parkinson's disease. This includes the use of wearable devices and remote technologies. Additionally, I use electronic health record data to understand care patterns for adults post-stroke, specifically linked to rehabilitation access and services.
Health Outcomes Research in Acute Myeloid Leukemia
My research is in acute leukemia and myeloid malignancies, specifically looking at health outcomes for older patients and TP53 mutations. Research would be based in chart review, submitting retrospective studies to the IRB and/or patient interactions focusing on patient reported outcomes. Please reach out if interested.