Distribution of Tau in Non-Amnestic Forms of Alzheimer's disease
We integrate high-resolution imaging and histology to develop new tests for Alzheimer's disease and related disorders.
Red Cell Immune Functions
My research objectives include understanding the role of the lung microvascular endothelium and red blood cells in regulating the innate immune response in the lung.
Neuroendocrinology and Metabolism
First, we study individuals with genetic disorders with characterized by risk for diabetes mellitus, including primary mitochondrial diseases and Friedreich's ataxia. Second, we focus on brain disorders associated with excess weight gain, including brain-tumor related hypothalamic obesity syndrome and idiopathic intracranial hypertension.
Sleep and brain development
We use the powerful model organism Drosophila to study the regulation and function of sleep during brain development.
Complex Brain Disorders
The lab aims to advance the understanding and treatment of complex brain disorders such as schizophrenia and related psychotic disorders.
Cancer Development
Investigating the mechanisms of breast cancer development and progression.
Exosome Therapy for Heart Failure
Utilize cell derived exosomes delivered via hydrogel into the heart muscle to enhance function and heart muscle growth.
Liver and kidney transplant research
Projects vary, but in general we use databases to understand opportunities to improve access to transplantation and study outcomes in various transplant populations.
Neuroblastoma developmental therapeutics
1. Familial Neuroblastoma.
2. ALK as a Tractable Molecular Target in Neuroblastoma.
3. Translational Research and Innovative Therapy Development.
4. Antibody Targeting of the Anaplastic Lymphoma Kinase Oncogene.