Scanzello Lab for Translational Osteoarthritis Research
Our laboratory focuses on understanding the stimuli and clinical consequences of immune system activation and inflammation in osteoarthritis (OA) and related joint injuries, with the goal of developing novel therapeutics to treat this debilitating joint disease. OA is the most common musculoskeletal disease and a leading cause of chronic joint pain and musculoskeletal disability worldwide.
Dynamics of cell identity establishment in the embryo
We study the dynamics of fundamental cellular processes in developing cells; and apply single-cell imaging and sequencing approaches to uncover principles that drive cell identity establishment and how these can be dysregulated in disease states.
Using chemistry to better identify and treat cancer
Our organic and chemical biology lab, in close collaboration with clinicians, is on a mission to develop molecules to treat or identify tumors in efforts to improve the lifespan of cancer patients.
Cloud computing-based platforms in biomedical data science
Cloud computing for health and disease
Cerebrovascular Neurosurgery Imaging Research
Dr Choudhri is a cerebrovascular and endovascular neurosurgeon who focuses on treatment of blood vessels disorders. His research encompasses novel imaging methods for cerebrovascular conditions such as brain aneurysms, stroke, pulsatile tinnitus.
Respiratory Viruses (Coronaviruses & Influenza)
Zoonotic viral pathogens have caused the largest known epidemics and pandemics throughout human history. My research centers on understanding key virus–host interactions and their impact on viral replication and pathogenesis, and to use these insights to develop novel methodologies to alleviate human disease.
Immunoengineering for Cardiovascular Disease
Cardiovascular disease is the leading cause of death worldwide. There is an urgent clinical need for treatments distinct from current options. To tackle this problem, we leverage the immune system, protein engineering, and pharmacokinetic modeling.
Global health - advancing child health in Consuelo, a rural town in the Dominican Republic
CHOP's Global Health Center and our Dominican partners have developed a program that aims to improve the health of children in the rural town of Consuelo.
Precise Genome Editing and Engineering for Human Health
We welcome highly motivated undergraduate researchers to work together!
Clinical Research in Mitochondrial Disease
Clinical research opportunities available at various times throughout the year focused on the care of children and adults with mitochondrial disease.