Unraveling the molecular mechanisms underlying TDP-43 proteinopathies.
In our lab, we study the molecular mechanisms underlying TDP-43 proteinopathies, which include frontotemporal degeneration (FTD-TDP), amyotrophic lateral sclerosis (ALS), and Alzheimer's disease (AD), among others. We employ both in vitro and in vivo models to replicate neuropathological features, aiming to elucidate the mechanisms of neurodegeneration.
Menstrual Health Equity
I explore menstrual health equity among adolescents and young adults in the United States.
Head and neck cancer research
Our lab studies the molecular biology of head and neck cancer
Scanzello Lab for Translational Osteoarthritis Research
Our laboratory focuses on understanding the stimuli and clinical consequences of immune system activation and inflammation in osteoarthritis (OA) and related joint injuries, with the goal of developing novel therapeutics to treat this debilitating joint disease. OA is the most common musculoskeletal disease and a leading cause of chronic joint pain and musculoskeletal disability worldwide.
Dynamics of cell identity establishment in the embryo
We study the dynamics of fundamental cellular processes in developing cells; and apply single-cell imaging and sequencing approaches to uncover principles that drive cell identity establishment and how these can be dysregulated in disease states.
Using chemistry to better identify and treat cancer
Our organic and chemical biology lab, in close collaboration with clinicians, is on a mission to develop molecules to treat or identify tumors in efforts to improve the lifespan of cancer patients.
Cloud computing-based platforms in biomedical data science
Cloud computing for health and disease
Cerebrovascular Neurosurgery Imaging Research
Dr Choudhri is a cerebrovascular and endovascular neurosurgeon who focuses on treatment of blood vessels disorders. His research encompasses novel imaging methods for cerebrovascular conditions such as brain aneurysms, stroke, pulsatile tinnitus.
Respiratory Viruses (Coronaviruses & Influenza)
Zoonotic viral pathogens have caused the largest known epidemics and pandemics throughout human history. My research centers on understanding key virus–host interactions and their impact on viral replication and pathogenesis, and to use these insights to develop novel methodologies to alleviate human disease.
Immunoengineering for Cardiovascular Disease
Cardiovascular disease is the leading cause of death worldwide. There is an urgent clinical need for treatments distinct from current options. To tackle this problem, we leverage the immune system, protein engineering, and pharmacokinetic modeling.