Clinical Cardiac Electrophysiology, Pediatric and Adult Congenital Cardiac Electrophysiology
Clinical cardiac electrophysiologist interested in collaborating and provide mentorship to develop predictive tools and tech to solve real world problems in the world of cardiac rhythm disorders and pacing
Research on coma and consciousness
Interested in how the brain sustains consciousness, the pathophysiology of coma, the prediction of recovery after brain injury, Neuroimaging, or philosophy of mind? The Recovery of Consciousness Via Evidence-Based Medicine and Research (RECOVER) Program is a unique initiative at Penn that integrates clinical care and research for patients in coma.
Feline and Canine DNA Database
The WSAVA-PennGen website allows the user to find DNA tests that are offered for cats and dogs along with the description of the diseases. By updating this website, the student will learn about genetic diseases in dogs and cats.
Head and Neck Paragangliomas
Head and neck paragangliomas are rare tumors with high rates of germline mutations. We are building a REDCAP database of a cohort of patients with head and neck paraganglioma and performing retrospective analysis of the cohort. We need help on data entry and verification. Data management and statistical analysis skills are helpful but not required.
Developing tools for deep-dive evaluation of data types
Director of the ITMAT Bioinformatics Laboratory. We do methods development, methods benchmarking and collaborative data analyses with emphasis on RNA and RNA sequencing and also circadian biology.
Studying the dialogue between the microbiome and the immune system
Our lab studies the effect of the microbiome on the immune system in health, disease and therapy.
Research in Reproductive Immunology
We study how inflammation in the uterus helps the embryo to implant and develop its placenta.
Genome engineering of human induced pluripotent stem cells to study blood disorders
Human induced pluripotent stem cells (iPSCs) are somatic cells that have been reprogrammed to a pluripotent state that allows them to differentiate into any cell type. The ability to genetically engineer iPSCs is essential for generating tools to study human diseases and biological processes.
Models of Genetic Neurodevelopmental Disorders
My lab studies rare genetic neurodevelopmental disorders that disrupt glycosylation (the enzyme-mediated process by which a carbohydrate, or “glycan”, is covalently attached to a target macromolecule) known as Congenital Disorders of Glycosylation, or CDG. In the nervous system, key proteins involved in neurotransmitter release, neuronal cell signaling, and cellular migration events are glycosylated, yet our understanding of the role of glycosylation in these processes is rudimentary. The scholar will use model systems (primary cells, iPSCs, mouse), a variety of molecular and cell biology techniques, and glycoproteomics to study glycosylation in the brain.