Robotic Fabrication & Generative Design
The Autonomous Manufacturing Lab combines research into computational approaches to architectural design with autonomous robot manufacturing capabilities, leveraging computer vision, machine learning and multi-agent systems to develop behavior-based approaches to design, fabrication and construction.
Pricing, New Product Launch, Digital Marketing, Advertising, Marketing
Pricing, New Product Launch, Retailing, E-Commerce
Urban Digital Humanities
This project joins urban and architectural history through the creation and interpretation of of maps, oral histories, databases, and narratives about neighborhood change.
Urbanization In Developing Countries
Interested in cities in developing countries, in particular Brazil, India, and Indonesia.
Sudden Cardiac Death Prevention
The research student works with a mentor in the Electrophysiology (Arrhythmia) Section of the Pediatric Cardiology Division at CHOP (Dr. Vetter) on a project related to conditions that can result in sudden cardiac arrest in children, Automated External Defibrillators (AEDs) in schools, or associated areas.
Integrated Circuits For Imaging, Sensing, Communication, and Autonomous Systems
Electronic and photonic circuit design for imaging, communication, and bio-technology.
Persian literary historiography, Persian language and literature, history of Modern Iran
Exile and Prison Literature in the Persianate World
Undergraduate Laboratory Research Assistant in Immunology
The Oliver lab is focused on understanding basic mechanisms that explain how our immune system protects us against pathogenic infection and prevents inflammation and consequent tissue damage.
Ovarian Cancer and Cellular Senescence
EPIGENETICS OF EPITHELIAL OVARIAN CANCER
A major discovery in recent cancer genome-wide sequencing is the identification of significant genetic changes in chromatin-modifying genes. However, despite great strides in identifying the various epigenetic enzymes/factors involved in cancer, the translational application of these findings in cancer intervention remains to be explored. The Zhang lab will pursue these issues in the coming years by focusing on the epigenetic SWItch/Sucrose Non-Fermentable (SWI/SNF) and Polycomb repressive complex 2 (PRC2) complexes as proof of principles in the context of ovarian cancer.
a. Mechanism-guided therapeutic strategies for genetic alterations that affect the SWI/SNF chromatin remodeling complex in epithelial ovarian cancer (such as ARID1A mutation in clear cell and endometrioid subtypes of ovarian cancer, and CARM1 amplification/overexpression in high-grade serous ovarian cancer).
b. Epigenetic approaches to chemotherapy resistance and cancer stemness in epithelial ovarian cancer.
c. Epigenetic approaches to primer for and/or synergize with immunological therapy in epithelial ovarian cancer.
d. PARP inhibitors resistance mechanism and approaches to sensitizing BRCA-proficient ovarian cancer to PARP inhibitors.
EPIGENETIC AND METABOLIC BASIS OF CELLULAR SENESCENCE
Cellular senescence is a state of stable cell growth arrest that is accompanied by drastic molecular and phenotypic changes. Cellular senescence is a major contributor to tissue aging and plays a context-dependent role in tumor development. For example, cellular senescence is tumor suppressive and overcoming the senescence-associated cell growth arrest is a necessary step during cell transformation. In contrast to its tumor suppressive function, senescent cells can also promote cancer by acquiring a secretory phenotype and create a pro-tumorigenic microenvironment. The biological process of cellular senescence represents an ideal paradigm to examine the role of the DNA damage response, epigenetically determined chromatin structure, and metabolic reprogramming during tissue aging and cancer development.
a. Chromatin basis of the senescence-associated secretory phenotype.
b. Targeting senescence-associated metabolic vulnerability to develop cancer therapeutics.
c. Targeting senescence-associated immunological vulnerability to develop cancer therapeutics.