Researching Cognitive Dysfunction Following Traumatic Brain Injury
My long-term research goals are to understand the mechanisms underlying cognitive dysfunction following traumatic brain injury (TBI) and to develop neuromodulation therapies for patients and veterans with TBI.
Brain tumor model characterization
We are characterizing humanized mouse models for the study of immunotherapy in glioblastoma, the most common adult malignant brain tumor. Using patient hematopoietic stem cells, we are able to establish a human immune system in an immunodeficient mouse. Tumor implantation then allows for the study of tumor-immune system interactions and therapeutics.
Developmental biology and genetic underpinnings of craniofacial development
The mission of our lab is to make a positive impact in science, in our team members and for patients everywhere. Our research program focuses on understanding the developmental biology and genetic underpinnings of craniofacial development. We are particularly interested in translating fundamental discoveries to clinical impact. Current projects include investigations of transcription factors important in regulating embryonic epithelial biology and neural crest differentiation, and the clinical malformations associated with this biology. We utilize the state-of-art approaches of genomics and cell biology in zebrafish, mouse and human iPSC models to mechanistically analyze these topics.
Pediatric Dentistry
My research interests include investigating oral health disparities among Asian American populations, children’s temperament and parenting styles and how this affects acceptance of dental treatment, and having a better understanding of medically complex pediatric patients and oral health considerations.
Pediatric Anesthesiologist at CHOP Seeking Motivated Students Interested in Biomedical Research
Research position for motivated undergraduate student interested in topics on EEG signal processing, machine learning, biomedical informatics to improve outcomes, or hospital sustainability topics.
Intestinal homeostasis, inflammation, and cancer: From in vivo studies to cellular and molecular mechanisms
Join us to study how the local tissue microenvironment controls homeostasis and disease in the gut, with in vivo, in vitro, and in silico approaches.
Microbial Genomics and Microbiomics
Join the CHOP Microbiome Sequencing Core and the microbialARC initiative, focusing on establishing a comprehensive strain repository. Our research spans bacterial pathogenesis, microbe-microbe interactions, and microbial evolution.
Improving Obstetric Anesthesia Procedures
Improving obstetric anesthesia procedures
Cellular therapies for cancer
Dr. Xu’s lab is dedicated to developing immunotherapies using engineered gamma delta T cells, extracellular vesicles, and nanoparticles to treat melanoma and other skin conditions.