Genetic risk factors of epilepsies and Friedreich's ataxia
My research is on the circuit basis of Friedreich's ataxia and genetic epilepsies. We use research techniques ranging from basic molecular approaches to computation to dissect the pathological mechanisms by which genetic mutations lead to those disorders.
Predicting Pregnancy Complications
Our research program aims to identify causes of placental dysfunction that contribute to pregnancy complications.
Gastroenterology (Internal Medicine): Patient-Oriented Clinical Research in Adults with Inflammatory Bowel Diseases (IBD)
Patient-oriented clinical research in adults with inflammatory bowel diseases (IBD).
Brain tumor model characterization
My lab develops new immunotherapy-based treatments for glioblastoma. We focus on cell engineering, modifying a variety of immune cells and redirecting them to attack the tumor. We are also characterizing humanized mouse models for the study of immunotherapy in glioblastoma, the most common adult malignant brain tumor. Using patient hematopoietic stem cells, we are able to establish a human immune system in an immunodeficient mouse. Tumor implantation then allows for the study of tumor-immune system interactions and therapeutics.
Developmental biology and genetic underpinnings of craniofacial development
The mission of our lab is to make a positive impact in science, in our team members and for patients everywhere. Our research program focuses on understanding the developmental biology and genetic underpinnings of craniofacial development. We are particularly interested in translating fundamental discoveries to clinical impact. Current projects include investigations of transcription factors important in regulating embryonic epithelial biology and neural crest differentiation, and the clinical malformations associated with this biology. We utilize the state-of-art approaches of genomics and cell biology in zebrafish, mouse and human iPSC models to mechanistically analyze these topics.
Pediatric Anesthesiologist at CHOP Seeking Motivated Students Interested in Biomedical Research
Research position for motivated undergraduate student interested in topics on EEG signal processing, machine learning, biomedical informatics to improve outcomes, or hospital sustainability topics.
Intestinal homeostasis, inflammation, and cancer: From in vivo studies to cellular and molecular mechanisms
Join us to study how the local tissue microenvironment controls homeostasis and disease in the gut, with in vivo, in vitro, and in silico approaches.
Microbial Genomics and Microbiomics
Join the CHOP Microbiome Sequencing Core and the microbialARC initiative, focusing on establishing a comprehensive strain repository. Our research spans bacterial pathogenesis, microbe-microbe interactions, and microbial evolution.
Improving Obstetric Anesthesia Procedures
Improving obstetric anesthesia procedures